The honor was just the most recent in a string of accolades. Moonlight is the same flick that shook up the Oscars after presenters Warren Beatty and Faye Dunaway mistakenly announced La La Land the winner of the Best Picture category.
Now, Moonlight is shaking things up once again as the only kiss nominated to have taken place between two males.
Here's the scene that won the gold:
While the actors' speech was short and sweet, it was strong.
"This award is bigger than Jharrel and I," Sanders said as he stood on stage. "This represents more than a kiss. This is for those who feel like the others, the misfits...we love ya'll and thank ya'll."
The Moonlight actors beat out Emma Stone and Ryan Gosling for La La Land, Emma Watson and Dan Stevens for Beauty and the Beast, Taraji P. Henson and Terrence Howard for Empire, and Zac Efron and Anna Kendrick for Mike & Dave Need Wedding Dates.
The 2017 MTV Movie & TV Awards airs on MTV 8 p.m. PST.